S100A9 induces monocyte/ macrophage migration via EMMPRIN

Vasileia Ismini Alexaki; Andreas E. May; Chika Fujii; Saskia N. I. v. Ungern-Sternberg; Christine Mund; Meinrad Gawaz; Triantafyllos Chavakis; Peter Seizer

doi:10.1160/TH16-06-0434

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2017; 117(03): 636-639
DOI: 10.1160/TH16-06-0434

Letters to the Editor

Schattauer GmbH

S100A9 induces monocyte/ macrophage migration via EMMPRIN

Authors

Vasileia Ismini Alexaki

¹Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany
Andreas E. May

²Medizinische Klinik III, Universitätsklinikum Tübingen, Tübingen, Germany

³Medizinische Klinik I, Klinikum Memmingen, Memmingen, Germany
Chika Fujii

¹Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany
Saskia N. I. v. Ungern-Sternberg

²Medizinische Klinik III, Universitätsklinikum Tübingen, Tübingen, Germany
Christine Mund

¹Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany
Meinrad Gawaz

²Medizinische Klinik III, Universitätsklinikum Tübingen, Tübingen, Germany
Triantafyllos Chavakis^*

¹Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Medical Faculty, Technische Universität Dresden, Dresden, Germany
Peter Seizer^*

²Medizinische Klinik III, Universitätsklinikum Tübingen, Tübingen, Germany

Abstract

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References

References
1 Gross SR, Sin CG, Barraclough R. et al. Joining S100 proteins and migration: for better or for worse, in sickness and in health. Cell Mol Life Sci 2014; 71: 1551-1579.
2 Donato R, Cannon BR, Sorci G. et al. Functions of S100 Proteins. Curr Mol Med 2013; 13: 24-57.
3 Goyette J, Geczy CL. Inflammation-associated S100 proteins: new mechanisms that regulate function. Amino Acids 2011; 41: 821-842.
4 Foell D, Wittkowski H, Vogl T. et al. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 2007; 81: 28-37.
5 Foell D, Frosch M, Sorg C. et al. Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation. Clin Chim Acta 2004; 344: 37-51.
6 Ryckman C, Vandal K, Rouleau P. et al. Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion. J Immunol 2003; 170: 3233-3242.
7 Ryckman C, McColl SR, Vandal K. et al. Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum 2003; 48: 2310-2320.
8 Manitz MP, Horst B, Seeliger S. et al. Loss of S100A9 (MRP14) Results in Reduced Interleukin-8-Induced CD11b Surface Expression, a Polarized Microfilament System, and Diminished Responsiveness to Chemoattractants In Vitro. Mol Cell Biol 2003; 23: 1034-1043.
9 Raquil MA, Anceriz N, Rouleau P. et al. Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia. J Immunol 2008; 180: 3366-3374.
10 van Zoelen M A D, Vogl T, Foell D. et al. Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis. Am J Resp Crit Care 2009; 180: 1098-1106.
11 Simard JC, Cesaro A, Chapeton-Montes J. et al. S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-kappaB(1). PLoS One 2013; 08: e72138.
12 Chen B, Miller AL, Rebelatto M. et al. S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo. PLoS One 2015; 10: e0115828.
13 Hofmann MA, Drury S, Fu CF. et al. RAGE mediates a novel proinflammatory axis: A central cell surface receptor for S100/calgranulin polypeptides. Cell 1999; 97: 889-901.
14 Bjork P, Bjork A, Vogl T. et al. Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides. PLoS Biol 2009; 07: e97.
15 Chavakis T, Bierhaus A, Al-Fakhri N. et al. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J Exp Med 2003; 198: 1507-1515.
16 Orlova VV, Choi EY, Xie CP. et al. A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. Embo J 2007; 26: 1129-1139.
17 Bjork P, Kallberg E, Wellmar U. et al. Common interactions between S100A4 and S100A9 defined by a novel chemical probe. PLoS One 2013; 08: e63012.
18 Muramatsu T. Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. J Biochem 2016; 159: 481-490.
19 Seizer P, Gawaz M, May AE. Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases. Cardiovasc Res 2014; 102: 17-23.
20 Sturhan H, von Ungern-Sternberg S N I, Langer H. et al. Regulation of EMMPRIN (CD147) on monocyte subsets in patients with symptomatic coronary artery disease. Thromb Res 2015; 135: 1160-1164.
21 Seizer P, Schonberger T, Schott M. et al. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. Atherosclerosis 2010; 209: 51-57.
22 Seizer P, Ochmann C, Schonberger T. et al. Disrupting the EMMPRIN (CD147)-Cyclophilin A Interaction Reduces Infarct Size and Preserves Systolic Function After Myocardial Ischemia and Reperfusion. Arterioscl Throm Vas 2011; 31: 1377-U316.
23 Seizer P, Klingel K, Sauter M. et al. Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis. J Mol Cell Cardiol 2012; 53: 6-14.
24 Seizer P, Geisler T, Bigalke B. et al. EMMPRIN and its ligand Cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy. Int J Cardiol 2013; 163: 299-304.
25 Seizer P, Borst O, Langer HF. et al. EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction. Thromb Haemost 2009; 101: 682-686.
26 Schulz C, von Bruhl ML, Barocke V. et al. EMMPRIN (CD147/basigin) mediates platelet-monocyte interactions in vivo and augments monocyte recruitment to the vascular wall. J Thromb Haemost 2011; 09: 1007-1019.
27 Hahn JN, Kaushik DK, Yong VW. The role of EMMPRIN in T cell biology and immunological diseases. J Leukocyte Biol 2015; 98: 33-48.
28 Hibino T, Sakaguchi M, Miyamoto S. et al. S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis. Cancer Res 2013; 73: 172-183.
29 Heinzmann D, Bangert A, Muller AM. et al. The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis. PLoS One 2015; 10: e0124606.
30 Choi EY, Orlova VV, Fagerholm SC. et al. Regulation of LFA-1-dependent inflammatory cell recruitment by Cb1-b and 14-3-3 proteins. Blood 2008; 111: 3607-3614.
31 Garcia-Martin R, Alexaki VI, Qin N. et al. Adipocyte-Specific Hypoxia-Inducible Factor 2alpha Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation. Mol Cell Biol 2015; 36: 376-393.
32 Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 2001; 25: 402-408.
33 Chatzigeorgiou A, Chung KJ, Garcia-Martin R. et al. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 2014; 60: 1196-1210.